Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis
Authors' conclusion
Associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis was limited, the few studies exploring lower limb muscle measures were mainly secondary outcomes.
Study context
- Population
- Individuals with OA; studies of biomarkers and lower limb skeletal muscle function (PubMed, MEDLINE, CINAHL, EMBASE, Scopus, SPORTDiscus, Web of Science, inception to 8th August 2023)
- Participants
- 4,101 individuals24 studies
- Outcome
- Associations between biomarkers and lower limb skeletal muscle function
Methodological detailstwo independent reviewers
- Two independent reviewers
Pooled result
As reported in the abstract
Muscle strength and vitamin D: significant association, Hedge's g (SE 0.27; P = 0.03), k = 3 studies
0.58
Walking speed and high-sensitivity CRP: no significant association, Hedge's g (SE 0.05; P = 0.73), k = 3 studies
−0.02
Further pooled results
- Total biomarkers reported
- 93
- Inflammatory
- 35
- Metabolic
- 15
- Hormones
- 10
- Studies reporting muscle-specific biomarkers (n = 3 biomarkers)
- 1
- Studies reporting OA-specific markers (n = 5 markers)
- 6
Original publication
Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis. Arthritis Res Ther. Published 5 November 2024. doi:10.
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