Genetic association between atopic disease and osteoarthritis
Main finding · Asthma and knee OA (IVW, random effects)Result — go to the resultOdds ratio 1.04 95% CI 1.01–1.08Authors' conclusion
We found a significant correlation between the overall genetic architecture of asthma and OA, as well as an increased risk of developing OA in patients with genetic variants associated with asthma and allergic rhinitis; predominately, this risk was for the development of knee OA.
Study context
- Population
- European-ancestry samples; atopic disease summary statistics from the UK Biobank
- Comparison
- Genetically determined risk for atopic disease traits vs osteoarthritis (OA)
- Outcome
- Association between genetically determined risk for atopic disease and OA
Methodological detailsLinkage disequilibrium (LD) score regression, two-sample summary statistics, inverse-variance weighted (IVW), MR-Egger, maximum likelihood, weighted median and weighted mode
- LD score regression
- Two-sample summary statistics
- IVW, MR-Egger, maximum likelihood, weighted median and weighted mode
Main finding
Asthma and knee OA (IVW, random effects)
Odds ratio
1.04
95% CI 1.01–1.08
P = 0.0169
Genetically determined risk for atopic disease traitsvs OA
OR 1.04 (95% CI 1.01–1.08); P = 0.0169
As reported in the abstract
Further findings
Knee OA and atopic traits (IVW, fixed effects)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Allergic diseaseIVW (fixed effects) | 1.07 (1.01–1.14) | P = 0.0342 | |
| Allergic rhinitisIVW (fixed effects) | 1.07 (1.00–1.13) | P = 0.0368 | |
| AsthmaIVW (fixed effects) | 1.04 (1.01–1.07) | P = 0.0139 | |
| 0.512Odds ratio (log scale) |
OA at any site and asthma (IVW, fixed effects)
| OR (95% CI) | P value | ||
|---|---|---|---|
| AsthmaIVW (fixed effects) | 1.02 (1.00–1.04) | P = 0.0166 | |
| 0.512Odds ratio (log scale) |
Original publication
Genetic association between atopic disease and osteoarthritis. Osteoarthritis Cartilage. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →