Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis
Authors' conclusion
Collectively, our systems immunology approach highlights potential associations between Treg dysfunctionality and OA-related pain, providing new hypotheses into the adaptive immune system's contribution to OA-related pain.
Study context
- Population
- Patients with knee osteoarthritis (OA) with similar radiographic stage
- Participants
- 46 patients
- Comparison
- Low vs high WOMAC pain intensity
- Outcome
- Immunologic signature associated with OA-related pain
Methodological detailsomics profiling of peripheral blood, deep immunophenotyping, cytokine profiling, transcriptomics, T cell receptor analysis
- Omics profiling of peripheral blood
- Deep immunophenotyping
- Cytokine profiling
- Transcriptomics
- T cell receptor analysis
Main finding
As reported in the abstract
- T cell subsets correlated with WOMAC pain
- 19
Original publication
Immunologic Profiling Suggests an Association Between Treg Cell Dysfunction and Pain in Knee Osteoarthritis. Arthritis Rheumatol. Published 5 February 2026. doi:10.
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