Association Between Depressive Symptoms and Self-Reported Physical Activity in Persons With Knee Osteoarthritis
Main finding · PASE z score over timeResult — go to the resultβ −0.09 95% CI −0.20 to 0.01Authors' conclusion
Depressive symptoms may contribute to worse self-reported PA levels in persons with KOA.
Study context
- Population
- Osteoarthritis Initiative participants with radiographic knee OA (Kellgren-Lawrence grade ≥ 2)
- Participants
- 2,602 participants
- Exposure
- Depressive symptoms vs none
- Outcome
- Self-reported physical activity (PA) (PASE z scores) over time
- Follow-up
- First 4 visits
Methodological detailsmarginal structural models controlling for time-invariant and time-varying confounders
- Marginal structural models controlling for time-invariant and time-varying confounders
Main finding
PASE z score over time
β
−0.09
95% CI −0.20 to 0.01
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) |
|---|---|
| PASE z score by visit (depressive symptoms-by-time interactions) · visits 1–4Depressive symptoms vs No depressive symptoms · visit 1 · relationship nonlinear from first to fourth follow-up visit | −0.18 (−0.33 to −0.02) |
| PASE z score by visit (depressive symptoms-by-time interactions) · visits 1–4Depressive symptoms vs No depressive symptoms · visit 2 · relationship nonlinear from first to fourth follow-up visit | −0.05 (−0.22 to 0.11) |
| PASE z score by visit (depressive symptoms-by-time interactions) · visits 1–4Depressive symptoms vs No depressive symptoms · visit 3 · relationship nonlinear from first to fourth follow-up visit | −0.01 (−0.19 to 0.16) |
| PASE z score by visit (depressive symptoms-by-time interactions) · visits 1–4Depressive symptoms vs No depressive symptoms · visit 4 · relationship nonlinear from first to fourth follow-up visit | −0.11 (−0.29 to 0.08) |
Physical Activity Scale for the Elderly (PASE) z score by visit (depressive symptoms-by-time interactions) · visits 1–4
- Interaction terms not statistically significant
Original publication
Association Between Depressive Symptoms and Self-Reported Physical Activity in Persons With Knee Osteoarthritis. J Rheumatol. Published 15 February 2025. doi:10.
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