Asthma, social isolation and loneliness, and risk of incident osteoarthritis
Main finding · All OAResult — go to the resultHazard ratio 1.32 95% CI 1.29–1.35Authors' conclusion
In this cohort study of UK Biobank participants, asthma was related to increased risk of OA; such association was more pronounced among those with higher social isolation or loneliness score.
Study context
- Population
- UK Biobank participants without osteoarthritis (OA) at baseline57,573 incident OA
- Participants
- 448,920 participants
- Exposure
- Asthma vs no asthma
- Outcome
- Incident OA (knee, hip and hand OA) from hospital admission records
Methodological detailsCox regression
- Cox regression
Main finding
All OA · median 12.5 years follow-up
Hazard ratio
1.32
95% CI 1.29–1.35
Asthmavs Without asthma
HR 1.32 (95% CI 1.29–1.35)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Knee OA | 1.21 (1.16–1.25) | |
| Hip OA | 1.12 (1.07–1.18) | |
| Hand OA | 1.62 (1.42–1.85) | |
| 0.512Hazard ratio (log scale) |
Effect modification by social isolation and loneliness
- Social isolation and loneliness significantly modified the associations of asthma with OA
- P for interaction < 0.001
Asthma vs lifestyle risk factors
- Asthma was a stronger predictor of OA than smoking, alcohol and healthy diet
Original publication
Asthma, social isolation and loneliness, and risk of incident osteoarthritis. Arthritis Res Ther. Published 10 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →