Atopy is associated with osteoarthritis severity: Results from the KHOALA cohort
Main finding · End-stage radiographic OA (Kellgren-Lawrence grade 4)Result — go to the resultAdjusted odds ratio 2.46 CI 1.42–4.25Authors' conclusion
Atopy appears to be associated with the radiographic OA severity and increased requirement of knee joint replacement.
Study context
- Population
- French multicentre KHOALA cohort of patients with knee and/or hip osteoarthritis (OA); mean age 65.2 years, 68% women, mean BMI 29.3kg/m²
- Participants
- 66 vs 651
- Exposure
- Atopic vs non-atopic patients with knee and/or hip OA
- Atopicn = 66
- Non-atopicn = 651reference
- Outcome
- Symptomatic (WOMAC pain, stiffness, function) and structural (end-stage radiographic OA, Kellgren-Lawrence grade 4) severity of knee and hip OA
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
End-stage radiographic OA (Kellgren-Lawrence grade 4)
Adjusted odds ratio
2.46
CI 1.42–4.25
P = 0.001
By group
Atopicvs Non-atopic
aOR 2.46 (CI 1.42–4.25); P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| TKR in knee OA · 7 yearsAdjusted for age, sex and BMI | 1.99 (1.15–3.45) | P = 0.01 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| WOMAC pain score (/20)Unadjusted; non-significant after adjustment · association became non-significant after adjustment | P < 0.05 |
Total knee replacement (TKR) in knee OA · 7 years
- Atopy associated with a two-fold increase in the risk of TKR
WOMAC function and stiffness
- Atopy not associated with worse functional limitations or stiffness
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Atopy is associated with osteoarthritis severity: Results from the KHOALA cohort. Joint Bone Spine. Published 17 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →