Association Between Hand Synovitis and All‐Cause Mortality: A General Population‐Based Study
Main finding · All-cause mortalityResult — go to the resultAdjusted hazard ratio 1.26 95% CI 1.01–1.58Authors' conclusion
Hand synovitis, especially when bilateral or polyarticular, may serve as a marker of increased all-cause mortality risk
Study context
- Population
- Middle-aged and older adults in the population-based Xiangya Osteoarthritis Study (mean age 64.4 years, 57.9% women)393 deaths
- Participants
- 3,552 participants
- Exposure
- Ultrasound-detected hand synovitis vs no synovitis
- Outcome
- All-cause mortality
- Follow-up
- Mean 5.72 years
Methodological detailspopulation-based, Cox proportional hazards models, multivariable-adjusted
- Population-based
- Cox proportional hazards models, multivariable-adjusted
Main finding
As reported in the abstract
Adjusted hazard ratio
1.26
95% CI 1.01–1.58
Synovitisvs No synovitis
aHR 1.26 (95% CI 1.01–1.58)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality by laterality of hand synovitisBilateral synovitisvs No synovitis | 1.42 (1.03–1.96) | ||
| All-cause mortality by laterality of hand synovitisUnilateral synovitisvs No synovitis | 1.20 (0.93–1.54) | ||
| All-cause mortality by number of affected jointsOne jointvs No synovitis | 1.19 (0.91–1.57) | P for trend < 0.05 | |
| All-cause mortality by number of affected jointsMore than one jointvs No synovitis | 1.35 (1.02–1.80) | P for trend < 0.05 | |
| All-cause mortality, distal interphalangeal joint synovitis (exploratory analyses)Distal interphalangeal joint synovitisvs No synovitisExploratory analyses; strongest association observed | 1.82 (1.14–2.91) | ||
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Association Between Hand Synovitis and All‐Cause Mortality: A General Population‐Based Study. Arthritis Care Res (Hoboken). Published 17 August 2026. doi:10.
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