The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee osteoarthritis (OA): The Multicenter Osteoarthritis study
Main finding · Effusion-synovitis and/or Hoffa-synovitis, longitudinallyResult — go to the resultRelative risk 1.30 95% CI 1.16–1.46Authors' conclusion
CT-detected IA calcification in various tissues was associated with the presence of joint inflammation on MRI over 2 years.
Study context
- Population
- Middle-aged and older adults from the Multicenter Osteoarthritis study with knee CT and MRI (mean age 60.6±9 years, 56% female, mean BMI 28.5±5 kg/m²; 21.6% knees with radiographic OA)
- Participants
- 1,669 participants
- Exposure
- Any CT-detected intra-articular (IA) calcification vs none
- Outcome
- Presence of MRI effusion-synovitis and/or Hoffa-synovitis (MOAKS), longitudinally
- Follow-up
- 2 years
Methodological detailslongitudinal, Poisson regression with generalized estimating equations, adjusted for age, sex, race and BMI
- Longitudinal
- Poisson regression with generalized estimating equations
- Adjusted for age, sex, race and BMI
Main finding
As reported in the abstract
Effusion-synovitis and/or Hoffa-synovitis, longitudinally
Relative risk
1.30
95% CI 1.16–1.46
IA calcificationvs No IA calcification
RR 1.30 (95% CI 1.16–1.46)
Observational data: associations, not effects.
Further findings
Baseline prevalence
- Any IA calcification
- 9.2%
- Effusion-synovitis
- 30.0%
- Hoffa-synovitis
- 37.0%
- Effusion-synovitis and/or Hoffa-synovitis
- 50%
IA calcification in cartilage, meniscus and capsule
- Results were similar for IA calcification in the cartilage, meniscus, and capsule
Original publication
The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee OA: The Multicenter Osteoarthritis study. Osteoarthritis Cartilage. Published 5 May 2026. doi:10.
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