Relation of Intra‐Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study
Authors' conclusion
CT-detected IA mineralization was associated with risk of having more frequent, persistent, and worsening knee pain over 2 years.
Study context
- Population
- Participants of the Multicenter Osteoarthritis Study with knee radiographs and bilateral knee computed tomography (CTs) at baseline (mean age 61 years, 57% women, mean BMI 28.8 kg/m²)
- Participants
- 2,093 participants
- Exposure
- CT-detected intra-articular (IA) mineralization vs no IA mineralization
- Outcome
- Frequent knee pain (FKP), intermittent or constant knee pain worsening, and pain severity worsening
- Follow-up
- 2 years
Methodological detailsmulticentre, generalized linear mixed-effects models
- Multicentre
- Generalized linear mixed-effects models
Main finding
As reported in the abstract
Times more frequent intermittent or constant pain (95% CI)
Any IA mineralization in cartilage
1.86(1.20–2.78)
- Any IA mineralization in cartilage
- odds (frequent knee pain (FKP)) 2.0 (95% CI 1.38–2.78)
Observational data: associations, not effects.
Further findings
Prevalence of IA mineralization (knees) · baseline
- Knees with IA mineralization
- 10.2%
Higher burden of IA mineralization anywhere in the knee, all pain outcomes
- OR range
- 2.14 to 2.21
Original publication
Relation of Intra‐Articular Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the MOST Study. Arthritis Rheumatol. Published 15 October 2023. doi:10.
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