Intra‐Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study
Main finding · Cartilage worsening on MRI (any increase in MRI OA Knee Score, incl. incident damage)Result — go to the resultRelative risk 1.39 95% CI 1.04–1.88Authors' conclusion
CT-detected IA mineralization in the cartilage was associated with higher risk of MRI cartilage worsening in the same compartment and subregion over two years.
Study context
- Population
- Participants from the Multicenter Osteoarthritis Study with knee computed tomography (CT) and magnetic resonance imaging (MRI) scans (mean age 60 years, 56% female, mean body mass index (BMI) 29)
- Participants
- 1,673 participants
- Exposure
- Intra-articular (IA) mineralization on knee CT vs none
- Outcome
- Cartilage worsening on MRI (any increase in the MRI osteoarthritis (OA) Knee Score, including incident damage) in the corresponding locations
- Follow-up
- Two years'
Methodological detailsmulticentre, binomial regression with generalized estimating equations, adjusted for age, sex and BMI
- Multicentre
- Binomial regression with generalized estimating equations
- Adjusted for age, sex and BMI
Main finding
As reported in the abstract
Cartilage worsening on MRI (any increase in MRI OA Knee Score, incl. incident damage) · 2 years
Relative risk
1.39
95% CI 1.04–1.88
IA mineralization on knee CT (Boston University Calcium Knee Score >0)vs none
RR 1.39 (95% CI 1.04–1.88)
Observational data: associations, not effects.
Original publication
Intra‐Articular Mineralization on Computerized Tomography of the Knee and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study. Arthritis Rheumatol. Published 2 April 2024. doi:10.
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