Increased risk of osteoarthritis in patients with atopic disease
Main finding · Incident OA (Optum CDM, matched)Result — go to the resultAdjusted odds ratio 1.58 95% CI 1.55–1.62Authors' conclusion
This study demonstrates an increased incidence of OA in patients with atopic disease.
Study context
- Population
- Adults without pre-existing osteoarthrits (OA) or inflammatory arthritis, Optum Clinformatics Data Mart (CDM) (January 2003 to June 2019) and Stanford Research Repository (STARR) (January 2010 to December 2020)n=1 09,899 per group after matching
- Participants
- 117,346 vs 1,247,196
- Exposure
- Atopic disease vs matched non-exposed patients
- Asthma or atopic dermatitisn = 117,346
- Non-exposedn = 1,247,196reference
- Outcome
- Incident OA
Methodological detailspropensity score matching, claims data (Optum CDM) and electronic health record data (STARR)
- Propensity score matching
- Claims data (Optum CDM) and electronic health record data (STARR)
Main finding
Incident OA (Optum CDM, matched)
Adjusted odds ratio
1.58
95% CI 1.55–1.62
By group
Asthma or atopic dermatitisvs Non-exposed
aOR 1.58 (95% CI 1.55–1.62)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Incident OA, both asthma and atopic dermatitisvs non-exposed (Optum CDM) | 2.15 (1.93–2.39) | |
| Incident OA, asthmavs chronic obstructive pulmonary disease (Optum CDM) | 1.83 (1.73–1.95) | |
| Incident OA, replication cohort (STARR, with BMI data) | 1.42 (1.36–1.48) | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Increased risk of osteoarthritis in patients with atopic disease. Ann Rheum Dis. Published 27 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →