Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study
Authors' conclusion
Our study's findings showed that plasma ccf-mtDNA was highly expressed in patients with KOA compared with HC. Furthermore, ccf-mtDNA content is significantly associated with the severity and risk of KOA.
Study context
- Population
- Patients with knee OA and age-, sex- and body mass index (BMI)-matched healthy controlsKnee osteoarthritis (KOA) and healthy controls (HC)
- Participants
- 60 patients
- Exposure
- Patients with knee OA vs healthy controls
- Outcome
- Plasma ccf-mtDNA content (quantitative real-time polymerase chain reaction (qRT-PCR))
Methodological detailsmatched for age, sex and BMI
- Matched for age, sex and BMI
Main finding
As reported in the abstract
Plasma ccf-mtDNA content
KOA
2.44
median · IQR 1.10–3.79
HC
1.08
median · IQR 0.52–2.12
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| KOA risk, highvs low ccf-mtDNALogistic regression | 4.15 (1.71–10.07) | P = 0.002 | |
| 0.050.21520Odds ratio (log scale) |
Circulating cell-free mitochondrial DNA (ccf-mtDNA) across Kellgren-Lawrence (K-L) grades I-IV
- Sequential increase from class I to IV (P = 0.040)
- Correlation with K-L classification (r = 0.369, P = 0.004)
- Correlation with WOMAC scores (r = 0.343, P = 0.007)
- Spearman analysis
ccf-mtDNA, bilateral vs single KOA
- No significant difference (P = 0.083)
KOA risk, high vs low ccf-mtDNA
- Quartile analysis: significant dose-dependent association (P trend < 0.001)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study. Arthritis Res Ther. Published 18 November 2024. doi:10.
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