Fibroblast and myeloid cells with high mitochondrial RNA content represent biologically significant populations within the OA synovium
Authors' conclusion
These findings suggest high-pMT cells are viable and potentially disease relevant, with their exclusion possibly obscuring key aspects of OA pathophysiology.
Study context
- Population
- Human and mouse scRNA-seq datasets; knee OA synovium (human knee OA synovial dataset stratified by pain, GSE248,453)7 scRNA-seq datasets
- Comparison
- High-pMT inclusive vs conventionally filtered scRNA-seq QC pipelines
- Outcome
- Characteristics of high-pMT cells in OA synovium (correlation with dissociation-induced stress, apoptosis association, cell-type localisation, pathway enrichment)
Methodological detailsreanalysis of seven published human and mouse scRNA-seq datasets, quantile-based filtering to include high-pMT cells
- Reanalysis of seven published human and mouse scRNA-seq datasets
- Quantile-based filtering to include high-pMT cells
Main finding
As reported in the abstract
pMT vs dissociation-induced stress scores across all datasets: no correlation (R)
−0.036
Original publication
Fibroblast and myeloid cells with high mitochondrial RNA content represent biologically significant populations within the OA synovium. Osteoarthritis Cartilage. Published 12 October 2025. doi:10.
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