Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients
Authors' conclusion
This study demonstrates that serum from hand OA and knee OA patients evokes diverse cellular signalling patterns that differentiates hand OA, knee OA and healthy controls.
Study context
- Population
- Patients with knee OA or hand OA and healthy controls (serum samples)serum samples
- Participants
- 55 / 56 / 42
- Exposure
- Serum-induced signalling in hand OA vs knee OA vs healthy controls
- Knee OAn = 55
- Hand OAn = 56
- Healthy controlsn = 42reference
- Outcome
- Serum-induced cell-integrated signalling pathway activity (16 transcription factor luciferase reporter assays)
Methodological details16 cell-based transcription factor luciferase reporter assays, principal component analysis
- 16 cell-based transcription factor luciferase reporter assays
- Principal component analysis
Main finding
As reported in the abstract
Serum-induced pathway activity
- Differential serum-induced pathway activity between healthy controls, knee OA and hand OA
- Hand OA serum induced high MAPK-related AP1 activity
- Knee OA serum induced more SRE, ISRE and SOX9 activity (related to ELK1-SRF, STAT1-STAT2 and SOX9 activity)
- Principal component analysis: these differences differentiate hand OA from knee OA
Observational data: associations, not effects.
Further findings
- Hand and knee OA each clustered clearly in two different endotypes; no principal component identified for these subtypes within either group
Original publication
Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients. Rheumatology (Oxford). Published 18 November 2024. doi:10.
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