Osteoarthritis

The rational use of glucocorticoids may reduce the risk of readmission in menopausal women with knee osteoarthritis: results from a five-year longitudinal study

Arthritis Res TherPublished Longitudinal cohort study

Main finding · Early readmissionResult — go to the resultHazard ratio 0.04 95% CI 0.006 ≈0.284

Authors' conclusion

GC use reduced the risk of readmission in menopausal women with knee OA, although this effect diminished over time.

Study context

Population
Menopausal women with knee osteoarthritis (OA) treated at a tertiary hospital affiliated with Shanxi Medical University, followed up September 2018–September 2023
Participants
80 women
Exposure
GC use vs no GC use
Outcome
Risk of readmission
Methodological detailsfive-year follow-up, semi-variable coefficient shared Gamma frailty model (VCSGF), single tertiary hospital
  • Five-year follow-up
  • Semi-variable coefficient shared Gamma frailty model (VCSGF)
  • Single tertiary hospital

Main finding

Early readmission

Hazard ratio

0.04

95% CI 0.006 ≈0.284

GCsvs No GCs
HR 0.04 (95% CI 0.006 ≈0.284)

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeFold higher risk (95% CI)
Hospital admission with recurrent symptoms, by alcohol drinkingPatients who drink alcohol vs patients who do not · roughly3.35 (1.661~6.794)

Original publication

The rational use of glucocorticoids may reduce the risk of readmission in menopausal women with knee osteoarthritis: results from a five-year longitudinal study. Arthritis Res Ther. Published 6 February 2025. doi:10.1186/s13075-025-03495-x

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