Spondyloarthritis & psoriatic arthritis
The insula represents a key neurobiological pain hub in psoriatic arthritis
Authors' conclusion
For the first time, we demonstrate objectively that nociceptive and nociplastic pain mechanisms co-exist in PsA.
Study context
- Population
- PsA participants52% female
- Participants
- 46 participants
- Outcome
- Functional connectivity between insula seeds (anterior, mid, posterior) and whole brain, correlated with nociplastic pain (2011 ACR fibromyalgia criteria) and body pain (Numeric Rating Scale (NRS), 0-100)
Methodological detailsresting-state functional magnetic resonance imaging (fMRI), correction for age and sex, false discovery rate (FDR) correction for multiple comparisons
- Resting-state fMRI
- Correction for age and sex
- FDR correction for multiple comparisons
Main finding
As reported in the abstract
- Higher FM score: increased connectivity right anterior insula to DMN
- P < 0.05
- Higher FM score: increased connectivity right mid and left posterior insula to parahippocampal gyri
- P < 0.01 FDR
- Higher FM score: increased connectivity right mid insula to left frontal pole
- P = 0.001 FDR
- Overall pain correlated with connectivity of left posterior insula to thalamus
- P = 0.01 FDR
- Overall pain correlated with connectivity of left posterior insula to brainstem
- P = 0.002 FDR
Observational data: associations, not effects.
Original publication
The insula represents a key neurobiological pain hub in psoriatic arthritis. Arthritis Res Ther. Published 31 March 2025. doi:10.
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