Spondyloarthritis & psoriatic arthritis
Longitudinal association of early axial spondyloarthritis status at the time of diagnosis with disease activity over time: 10-year results from the German Spondyloarthritis Inception Cohort (GESPIC) cohort
Main finding · ASDAS, total effect of early axSpAResult — go to the resultTotal effect −0.42 95% CI −0.57 to −0.26Authors' conclusion
Fulfilment of the ASAS early axSpA definition at inclusion was associated with lower disease activity over 10 years.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in the German Spondyloarthritis Inception Cohort (GESPIC)277 nr-axSpA, 248 r-axSpA
- Participants
- 525 patients
- Exposure
- Early axSpA vs non-early axSpA
- Early axSpAn = 161
- Outcome
- Disease activity (Axial Spondyloarthritis Disease Activity Score (ASDAS))
- Follow-up
- Over 10 years
Methodological detailsinception cohort, 10-year longitudinal data, generalised estimating equations, confounders identified through a directed acyclic graph, stratification by radiographic status
- Inception cohort
- 10-year longitudinal data
- Generalised estimating equations
- Confounders identified through a directed acyclic graph
- Stratification by radiographic status
Main finding
ASDAS, total effect of early axSpA
Total effect
−0.42
95% CI −0.57 to −0.26
As reported in the abstract
Observational data: associations, not effects.
Further findings
ASDAS inactive disease or low disease activity · baseline
ASDAS inactive disease or low disease activity · year 10
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Longitudinal association of early axial spondyloarthritis status at the time of diagnosis with disease activity over time: 10-year results from the GESPIC cohort. RMD Open. Published 23 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →