Spondyloarthritis & psoriatic arthritis
Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients With and Without a Family History of Psoriatic Disease
Authors' conclusion
In this cohort, patients with PsA with a family history of psoriatic disease were diagnosed with psoriasis and PsA earlier and were more likely to have entheseal involvement compared to those without a family history.
Study context
- Population
- Patients with PsA enrolled in an observational, longitudinal registry
- Participants
- 843 patients
- Exposure
- PsA with vs without a family history of psoriatic disease
- Family historyn = 379
- Outcome
- Differences in onset, domain involvement and disease activity by family history of psoriatic disease
Main finding
As reported in the abstract
Age at psoriasis onset
P < 0.01
Observational data: associations, not effects.
Further findings
Age at PsA onset
P < 0.01
Entheseal involvement
P < 0.05
| Outcome | Family history | No family history | P value |
|---|---|---|---|
| Age at psoriasis diagnosis by relative's disease (FDR/SDR with PsA vs psoriasis alone vs none)Across the three groups | P < 0.01 | ||
| Age at PsA diagnosis by relative's disease (FDR/SDR with PsA vs psoriasis alone vs none)Across the three groups | — not stated in the abstract | mean 40.3 years | P = 0.01 |
— not stated in the abstract
- Age at psoriasis diagnosis by relative's disease (first-degree relative (FDR)/second-degree relative (SDR) with PsA vs psoriasis alone vs none): FDR/SDR with PsA mean 26.3 years
- Age at psoriasis diagnosis by relative's disease (FDR/SDR with PsA vs psoriasis alone vs none): FDR/SDR with psoriasis alone mean 27.8 years
- Age at PsA diagnosis by relative's disease (FDR/SDR with PsA vs psoriasis alone vs none): FDR/SDR with PsA mean 36.5 years
- Age at PsA diagnosis by relative's disease (FDR/SDR with PsA vs psoriasis alone vs none): FDR/SDR with psoriasis alone mean 37.9 years
Original publication
Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients With and Without a Family History of Psoriatic Disease. Arthritis Rheumatol. Published 21 September 2025. doi:10.
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