Spondyloarthritis & psoriatic arthritis
Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8 + T Cell Clones
Authors' conclusion
Our findings support the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell clonality and that specific T cells migrate between these compartments to propagate inflammation across both sites.
Study context
- Population
- Patients with psoriatic arthritis (PsA)six patients
- Participants
- 6 / 5 / 5
- Comparison
- CD8+ T cells from skin vs synovial tissue and/or fluid in PsA
- Skinn = 6
- Synovial tissuen = 5
- Synovial fluidn = 5
- Outcome
- CD8+ T cell phenotype and clonality linking skin and joint inflammation
Methodological detailssingle-cell RNA sequencing, spatial transcriptomics, paired skin and synovial samples
- Single-cell RNA sequencing
- Spatial transcriptomics
- Paired skin and synovial samples
Main finding
As reported in the abstract
CD8+ T cell clones shared between skin and joint across six patients
155
CD8+ T cells comprised by shared clones
1,071
Shared clones, median share of skin CD8+ TCR repertoire
13%
Shared clones, median share of joint CD8+ TCR repertoire
8%
Original publication
Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8 + T Cell Clones. Arthritis Rheumatol. Published 21 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →