Spondyloarthritis & psoriatic arthritis
XCR1 + Conventional Type 1 Dendritic Cells Exacerbate the Inflammation in Osteogenic Arthritis Through IL ‐ 17A + CD8 + T Cells
Authors' conclusion
Thus, cDC1s promote autoimmune reactions and osteoarticular lesions through IL-17A+CD8+ T cells.
Study context
- Population
- Lesions of patients with early RA, ankylosing spondylitis (AS) and enthesitis-related arthritis (ERA); versican peptide-induced AS mouse model
- Participants
- 33 patient specimens
Methodological detailssingle-cell RNA-sequencing, T cell receptor (TCR) profiling, flow cytometry, multiplex immunofluorescence, mouse model
- Single-cell RNA-sequencing
- TCR profiling
- Flow cytometry
- Multiplex immunofluorescence
- Mouse model
Main finding
As reported in the abstract
- cDC1s enriched in joints of ERA patients, with high major histocompatibility complex (MHC) I antigen presentation, interacting robustly with CD8+ T cells
- cDC1s with MHC I antigen presentation detected in spinal ligament tissue of AS patients
- Versican-derived peptide plus type II collagen elicited a mouse model with hallmark enthesitis and heterotopic ossification
- cDC1s and IL-17A+CD8+ T cells highly enriched in ligamentous synovial tissues of the model
- Blocking cDC1 recruitment with XCL1-neutralizing antibody alleviated arthritis in vivo
Original publication
XCR1 + Conventional Type 1 Dendritic Cells Exacerbate the Inflammation in Osteogenic Arthritis Through IL ‐ 17A + CD8 + T Cells. Arthritis Rheumatol. Published 9 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →