Spondyloarthritis & psoriatic arthritis
Effect of tumour necrosis factor inhibitors on risk of depression in patients with AS: a nationwide propensity score-matched cohort study
Main finding · Incident depressionResult — go to the resultAdjusted hazard ratio 0.82 95% CI 0.72–0.92Authors' conclusion
TNFi exposure was associated with a lower incidence of depression in patients with AS
Study context
- Population
- Patients with AS with no history of depression, Korean nationwide claims database1:1 propensity score-matched
- Participants
- 4,284 vs 4,284
- Exposure
- TNFi exposure vs TNFi non-exposure
- TNFi exposuren = 4,284
- TNFi non-exposuren = 4,284reference
- Outcome
- Incident depression
Methodological detailsnationwide, propensity score-matched (1:1), multivariable stratified Cox regression
- Nationwide
- Propensity score-matched (1:1)
- Multivariable stratified Cox regression
Main finding
As reported in the abstract
Adjusted hazard ratio
0.82
95% CI 0.72–0.92
P = 0.001
By group
TNFi exposurevs TNFi non-exposure
aHR 0.82 (95% CI 0.72–0.92); P = 0.001
Observational data: associations, not effects.
Original publication
Effect of tumour necrosis factor inhibitors on risk of depression in patients with AS: a nationwide propensity score-matched cohort study. Rheumatology (Oxford). Published 3 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →