Spondyloarthritis & psoriatic arthritis
Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27
Authors' conclusion
HLA-B27 drives the cytotoxicity of aging-related NKG2C + CD8 + T cells via activation of the PI3K-Akt signaling pathway.
Study context
- Population
- Patients with ankylosing spondylitis (AS) and matched controls; collagen-induced arthritis and HLA-B27 transgenic mouse modelspatients with AS
- Participants
- 87 patients
- Comparison
- AS patients vs matched controls
Methodological detailsmultidimensional flow cytometry, single-cell RNA sequencing, collagen-induced arthritis mouse model, HLA-B27 transgenic mice, RNA-sequencing
- Multidimensional flow cytometry
- Single-cell RNA sequencing
- Collagen-induced arthritis mouse model
- HLA-B27 transgenic mice
- RNA-sequencing
Main finding
As reported in the abstract
- Peripheral blood immune signature of AS patients showed dysregulation similar to that during aging
- NKG2C + CD8 + T cells activated the PI3K-Akt pathway and increased phagocytosis in AS patients
- HLA-B27 stimulation significantly increased cytotoxicity of NKG2C + CD8 + T cells, reversed by NKG2C blockade
- In HLA-B27 transgenic mice, Ly49h + T cells showed significantly enhanced degranulation
- RNA sequencing validated PI3K-Akt pathway activation in NKG2C + CD8 + T cells by HLA-B27
Original publication
Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27. Arthritis Res Ther. Published 14 June 2025. doi:10.
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