Spondyloarthritis & psoriatic arthritis
Impact of comorbidities and extra-musculoskeletal manifestations on radiographic progression in ankylosing spondylitis
Authors' conclusion
Comorbidity burden, uveitis and psoriasis are independently associated with greater spinal radiographic progression in AS.
Study context
- Population
- AS fulfilling modified New York criteria with ≥1 lateral cervical or lumbar radiograph (mean age 44 years; 75% male; 84% HLA-B27 positive)3,441 patient-years analysed
- Participants
- 1,150 participants
- Exposure
- Baseline comorbidity count and extra-musculoskeletal manifestations (EMMs) and spinal radiographic progression
- Outcome
- Spinal radiographic progression (mSASSS, range 0-48), mean difference in progression (units/10 years)
Methodological detailsgeneralized estimating equations, adjusted for baseline modified Stoke AS Severity Score (mSASSS), sex, symptom duration, CRP, HLA-B27, smoking, TNFi use, and number of EMMs or comorbidity count
- Generalized estimating equations
- Adjusted for baseline mSASSS, sex, symptom duration, CRP, HLA-B27, smoking, TNFi use, and number of EMMs or comorbidity count
Main finding
As reported in the abstract
mSASSS progression, mean difference (units/10 years)
Each group vs no comorbiditiesMean difference, units/10 years (95% CI)
Two comorbidities
2.7(1.9–3.5)
Three or more comorbidities
2.3(1.5–3.1)
Uveitis
2.2(1.3–3.0)
Psoriasis
2.4(1.4–3.5)
Observational data: associations, not effects.
Further findings
Sex-specific analyses
- Greater spinal progression in females than males with psoriasis
Segment-specific analyses
- Cervical-predominant changes with uveitis and psoriasis
Original publication
Impact of comorbidities and extra-musculoskeletal manifestations on radiographic progression in ankylosing spondylitis. Rheumatology (Oxford). Published 9 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →