Spondyloarthritis & psoriatic arthritis
Good construct validity of the CT Syndesmophyte Score (CTSS) in patients with radiographic axial spondyloarthritis
Authors' conclusion
The good agreement between syndesmophytes detected by CTSS and mSASSS and the strong correlation of CTSS with spinal mobility support the construct validity of the CTSS.
Study context
- Population
- Patients with r-axSpA (85% male, 85% HLA-B27+, mean age 48 years)41/48 for hypothesis 2
- Participants
- 48 patients
- Comparison
- CTSS on low-dose CT vs modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) on conventional radiography
- Outcome
- Hypothesis 1: syndesmophytes scored with CTSS also detected with mSASSS at baseline or 2 years later; hypothesis 2: CTSS non-inferior to mSASSS in correlations with spinal mobility measures
- Follow-up
- Baseline and 2 years
Methodological detailsconstruct validity, low-dose CT, 2-year follow-up
- Construct validity
- Low-dose CT
- 2-year follow-up
Performance
As reported in the abstract
Syndesmophytes on CTSS at baseline (corners out of 917) and correlation with spinal mobility measures and BASMI
| Test or model | Corners with syndesmophytes, reader 1 | Corners with syndesmophytes, reader 2 | Rs with spinal mobility measures and Bath Ankylosing Spondylitis Metrology Index (BASMI) |
|---|---|---|---|
| CTSS | 348 (38%) | 327 (36%) | 0.46-0.73 |
| mSASSS | 0.34-0.64 |
Corners with syndesmophytes, reader 1
CTSS348 (38%)
mSASSS— not stated in the abstract
Corners with syndesmophytes, reader 2
CTSS327 (36%)
mSASSS— not stated in the abstract
Rs with spinal mobility measures and Bath Ankylosing Spondylitis Metrology Index (BASMI)
CTSS0.46-0.73
mSASSS0.34-0.64
- CTSS syndesmophytes also seen on CR at baseline or after 2 years, depending on reader pairs
- 62%-79%
Original publication
Good construct validity of the CT Syndesmophyte Score (CTSS) in patients with radiographic axial spondyloarthritis. RMD Open. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →