Spondyloarthritis & psoriatic arthritis
Association between triglyceride-glucose index and carotid atherosclerosis in patients with psoriatic arthritis
Authors' conclusion
TyG index was positively correlated with the burden of atherosclerosis in PsA patients, independent of traditional cardiovascular risk factors and psoriatic-related factors.
Study context
- Population
- Consecutive PsA patients receiving carotid US with integrated triglyceride-glucose (TyG) index
- Participants
- 165 patients
- Exposure
- TyG index and carotid atherosclerosis
- Outcome
- Carotid atherosclerosis
Methodological detailsconsecutive patients, logistic regression, fully adjusted for sex, age, smoking, BMI, comorbidities and psoriatic-related variables
- Consecutive patients
- Logistic regression
- Fully adjusted for sex, age, smoking, BMI, comorbidities and psoriatic-related variables
Main finding
As reported in the abstract
Carotid atherosclerosis
8.82
SD 0.50
Without carotid atherosclerosis
8.54
SD 0.55
Tertile 1
14.8%
Tertile 2
34.5%
Tertile 3
44.6%
Estimate (CI)
Per 1-unit increase in TyG index
unadjusted OR 2.65(1.39–5.05)
Per 1-unit increase in TyG index
fully adjusted OR 2.69(1.02–7.11)
Tertile 3vs Tertile 1
unadjusted OR 4.64(1.85–11.60)
Tertile 3vs Tertile 1
fully adjusted OR 5.10(1.54–16.93)
Observational data: associations, not effects.
Further findings
Carotid artery plaque, with increasing TyG index (continuous)
| Estimate | ||
|---|---|---|
| Increasing TyG index | unadjusted OR 3.11 (CI 1.54–6.26) | |
| Increasing TyG index | fully adjusted OR 3.61 (CI 1.15–11.38) | |
| 0.050.21520Ratio (log scale) |
| Outcome | Estimate | |
|---|---|---|
| Carotid artery plaque, TyG index tertile 3 vs tertile 1Tertile 3vs Tertile 1 | unadjusted OR 10.20 (CI 2.83–36.82) | |
| Carotid artery plaque, TyG index tertile 3 vs tertile 1Tertile 3vs Tertile 1 | fully adjusted OR 17.89 (CI 2.88–111.11) | |
| 0.050.21520Ratio (log scale) |
Incremental predictive capacity of TyG index beyond established risk factors
- Increase in discrimination ability
- all P < 0.001
Original publication
Association between triglyceride-glucose index and carotid atherosclerosis in patients with psoriatic arthritis. Rheumatology (Oxford). Published 10 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →