Spondyloarthritis & psoriatic arthritis
Obesity is more strongly associated with physical performance and body composition than sarcopenia in patients with spondyloarthritis
Authors' conclusion
In SpA, DXA-defined obesity was common and associated with worse objective performance, whereas sarcopenia was rare. Higher levels of daily physical activity were independently associated with better physical performance and more favourable muscle-related body composition indices.
Study context
- Population
- Patients with axial SpA (axSpA) or psoriatic arthritis (PsA), single centreaxSpA or PsA
- Participants
- 213 patients
- Exposure
- Daily physical activity tertiles (mSQUASH) and DXA-derived body composition phenotypes
- Outcome
- Cross-sectional associations of DXA-derived body composition phenotypes with objective physical performance and daily physical activity
Methodological detailssingle-centre, ANCOVA adjusted for age, BMI and diagnosis
- Single-centre
- ANCOVA adjusted for age, BMI and diagnosis
Main finding
As reported in the abstract
Grip strength, highest mSQUASH tertile (significantly higher)
45.3 (13.0) kg
Gait speed, highest mSQUASH tertile (faster)
1.60 (0.27) m/s
SPPB score, highest mSQUASH tertile (higher)
11.5
1.0
Observational data: associations, not effects.
Further findings
Adjusted ANCOVA models
- Daily physical activity independently associated with ALM/BMI, grip strength and ASPI; diagnosis showed no independent association
- Adjusted for age, BMI and diagnosis
Body fat and obesity prevalence by treatment (sex-stratified)
- TNFi-treated men had lower body fat and obesity prevalence than men on conventional therapy; no differences in women
Original publication
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