Spondyloarthritis & psoriatic arthritis
Incremental value of carotid intima-media thickness beyond SCORE2 in identifying subclinical atherosclerosis in PsA
Authors' conclusion
cIMT improves SCORE2-based risk prediction in PsA, and exploratory analyses suggest that slightly lower thresholds (≈0.79 mm) may further enhance the detection of subclinical atherosclerosis.
Study context
- Population
- PsA patients fulfilling CASPAR criteria; atherosclerotic plaques assessed by US in carotid, femoral and abdominal aortic territories
- Participants
- 146 patients
- Exposure
- SCORE2 alone vs SCORE2+carotid intima-media thickness (cIMT) for detecting subclinical atherosclerosis
- Outcome
- Detection of multisite plaque (≥2 sites) by ROC analysis (AUC)
Main finding
As reported in the abstract
Detection of multisite plaque (≥2 sites), AUC
| Group | AUC |
|---|---|
| SCORE2 alone | 0.81 |
SCORE2 alone
AUC0.81
- Reclassification indices were modest: NRI
- ≈ 0.0
- Reclassification indices were modest: IDI
- 0.0006
Observational data: associations, not effects.
Further findings
Reclassification indices
- NRI (modest)
- ≈ 0.0
- IDI (modest)
- 0.0006
Correlation of SCORE2 with mean cIMT
- ρ
- 0.54
- P
- P < 0.001
Optimal cIMT cut-offs
mm
- Carotid and femoral plaques
- 0.79
- Aortic plaques
- 0.90
- 0.79 mm threshold provided a more favourable sensitivity-specificity balance for detecting multisite atherosclerosis
- Exploratory analyses (0.79 mm threshold)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incremental value of carotid intima-media thickness beyond SCORE2 in identifying subclinical atherosclerosis in PsA. Rheumatology (Oxford). Published 28 March 2026. doi:10.
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