Spondyloarthritis & psoriatic arthritis
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study
Authors' conclusion
Axial involvement was identified in 27.4% of participants with PsA after final diagnostic assessment, with associated features including HLA-B*27 positivity, IBP, elevated CRP, and imaging changes in SIJ or spine.
Study context
- Population
- Participants with psoriatic arthritis (PsA) meeting CASPAR criteria, musculoskeletal symptom duration ≤10 years, no prior b/tsDMARD exposure; 19 countries (ASAS and GRAPPA)
- Participants
- 409 participants
- Exposure
- PsA with vs without axial involvement
- Axial involvementn = 112
- Outcome
- Frequency of axial involvement in PsA
Methodological detailsprospective, multicentre, 19 countries, consecutive inclusion, central-imaging review
- Prospective
- Multicentre
- 19 countries
- Consecutive inclusion
- Central-imaging review
Main finding
As reported in the abstract
Axial involvement, final evaluation after central-imaging review
Axial involvement
27.4%
112
Observational data: associations, not effects.
Further findings
Age
Male sex
HLA-B*27 positivity
Inflammatory back pain
Elevated CRP
- Axial involvement, investigator's initial assessment
- 37.4% · 153
Imaging signs of axial involvement (active inflammation or structural lesions) on central review
- Participants with imaging signs on central review
- 95 (23.2%)
Discrimination by imaging
- Active inflammatory and structural imaging changes were highly discriminative between participants with and without axial involvement
Original publication
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study. Ann Rheum Dis. Published 26 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →