Spondyloarthritis & psoriatic arthritis
Chronic inflammatory burden on aortic valve disorders and atrioventricular block risk in SpA: an ambispective cohort study
Authors' conclusion
The duration of MSK symptoms more strongly predicted all outcomes than extra-MSK symptoms.
Study context
- Population
- SpA patients meeting ASAS criteria, September 2022 to April 2024
- Participants
- 461 patients
- Exposure
- Chronic inflammatory burden
- Outcome
- Aortic valve outcomes and AVB
Methodological detailsmultiple time-dependent Cox regression
- Multiple time-dependent Cox regression
Main finding
As reported in the abstract
Per 5-year increase in symptom duration
Aortic regurgitation, HR
1.21
95% CI 1.06–1.37
Valve sclerosis, HR
1.07
95% CI 1.02–1.12
Root dilation, HR
1.31
95% CI 1.08–1.59
Atrioventricular block (AVB), HR
1.34
95% CI 1.05–1.71
Observational data: associations, not effects.
Further findings
Age, per decade
- Aortic regurgitation, HR
- 1.46
- Valve sclerosis, HR
- 1.74
Hypertension
- Aortic root dilation, HR
- 0.55 (95% CI 0.36-0.84)
- Valve sclerosis, HR
- 0.62 (95% CI 0.40-0.96)
- Aortic regurgitation, HR
- 0.60 (95% CI 0.37-0.98)
Peripheral SpA and aortic valve sclerosis
- HR
- 1.95 (95% CI 1.13-3.36)
Enthesitis and AVB
- HR
- 3.04 (95% CI 1.24-7.44)
Original publication
Chronic inflammatory burden on aortic valve disorders and atrioventricular block risk in SpA: an ambispective cohort study. Rheumatology (Oxford). Published 5 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →