Spondyloarthritis & psoriatic arthritis
Patients with psoriatic arthritis and comorbid metabolic syndrome show a difficult-to-treat phenotype: another mosaic tile in the definition of a still undefined subset of patients
Authors' conclusion
MetS is strongly associated with a D2T phenotype in PsA, suggesting that metabolic comorbidities contribute to disease severity and treatment resistance.
Study context
- Population
- Psoriatic arthritis (PsA) patients fulfilling CASPAR criteria, Rheumatology Clinic, Fondazione Policlinico Campus Bio-Medico of Rome42.94% met metabolic syndrome (MetS) criteria
- Participants
- 182 patients
- Exposure
- Difficult-to-treat (D2T) PsA vs non-D2T PsA, prevalence of MetS
- D2Tn = 66
- Outcome
- Association between MetS (NCEP ATP III criteria) and D2T PsA
Methodological detailssingle-centre, logistic regression, path analysis
- Single-centre
- Logistic regression
- Path analysis
Main finding
As reported in the abstract
Prevalence of MetS
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Association of MetS with D2T PsA (logistic regression)MetSvs No MetS | 7.56 (2.53–22.56) | P < 0.0001 | |
| 0.050.21520Odds ratio (log scale) |
Association of MetS with D2T PsA (logistic regression)
- Path analysis confirmed MetS as an independent predictor of D2T phenotype
Original publication
Patients with psoriatic arthritis and comorbid metabolic syndrome show a difficult-to-treat phenotype: another mosaic tile in the definition of a still undefined subset of patients. RMD Open. Published 22 June 2025. doi:10.
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