Spondyloarthritis & psoriatic arthritis
Difficult-to-Treat Concept in Psoriatic Arthritis: Analysis of 2 Potential Definitions in a Large Group of Patients. A Cross-Sectional Study
Authors' conclusion
Our study compared 2 published sets of criteria showing comparable performance and substantial agreement.
Study context
- Population
- Patients with psoriatic arthritis (PsA) fulfilling CASPAR, with at least 1 year of follow-up, 2 longitudinal cohorts219 male/159 female
- Participants
- 378 patients
- Exposure
- Difficult-to-treat (D2T) PsA criteria proposed by Perrotta et al vs criteria proposed by Kumthekar et al
- Outcome
- Performance of 2 proposed criteria for D2T PsA and agreement between the 2 sets of criteria
Methodological detailscross-sectional analysis of 2 longitudinal cohorts, external validator (absence of PASS + PGA ≥ 6 cm)
- Cross-sectional analysis of 2 longitudinal cohorts
- External validator (absence of PASS + PGA ≥ 6 cm)
Main finding
As reported in the abstract
Performance of 2 D2T PsA criteria sets vs external validator (absence of PASS + PGA ≥ 6 cm), and agreement between them
| Group | Value | Sensitivity | Specificity |
|---|---|---|---|
| Perrotta | 19.8% | 37.8% | 82.1% |
| Kumthekar | 15.3% | 29.7% | 86.2% |
Value
Perrotta19.8%
Kumthekar15.3%
Sensitivity
Perrotta37.8%
Kumthekar29.7%
Specificity
Perrotta82.1%
Kumthekar86.2%
- Agreement between the 2 sets of criteria (Fleiss kappa): substantial
- 0.72
Observational data: associations, not effects.
Original publication
Difficult-to-Treat Concept in Psoriatic Arthritis: Analysis of 2 Potential Definitions in a Large Group of Patients. A Cross-Sectional Study. J Rheumatol. Published 15 July 2024. doi:10.
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