Spondyloarthritis & psoriatic arthritis
Identification and characteristics of patients with potential difficult-to-treat psoriatic arthritis: exploratory analyses of the Greek PsA registry
Authors' conclusion
Despite the availability of therapies, D2T PsA is common in real-life cohorts of patients with PsA and extensive psoriasis. High BMI, female gender, axial disease and history of IBD were also associated with D2T PsA.
Study context
- Population
- PsA patients in the Greek multicentre PsA registry
- Participants
- 467 patients
- Exposure
- Difficult-to-treat (D2T) vs non-D2T PsA
- D2Tn = 77
- Non-D2Tn = 390reference
- Outcome
- Characteristics of patients with potential D2T PsA
Methodological detailsmulticentre, exploratory analyses, sensitivity analyses
- Multicentre
- Exploratory analyses
- Sensitivity analyses
Main finding
As reported in the abstract
D2T
16.5%
77
D2T vs Non-D2T: P < 0.0001 · D2T vs Non-D2T: P = 0.023 · D2T vs Non-D2T: P = 0.026
Observational data: associations, not effects.
Further findings
Sensitivity analysis: D2T by moderate disease activity (MODA) criterion only
- Patients considered D2T
- 7.5%
- Extensive psoriasis independent variable for D2T
- P = 0.001
- Female gender independent variable for D2T
- P = 0.034
Sensitivity analysis: D2T by minimal disease activity (MDA) criterion only
- Patients considered D2T
- 12.5%
- Extensive psoriasis independent variable for D2T
- P = 0.008
- Axial disease independent variable for D2T
- P = 0.040
Original publication
Identification and characteristics of patients with potential difficult-to-treat psoriatic arthritis: exploratory analyses of the Greek PsA registry. Rheumatology (Oxford). Published 17 May 2024. doi:10.
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