Spondyloarthritis & psoriatic arthritis
Sex Differences in Time to Initiate Nonsteroidal Anti‐Inflammatory Drugs or Biologic Disease‐Modifying Antirheumatic Drugs Among Patients With Axial Spondyloarthritis
Main finding · Time to NSAID initiation (those without ≥2 different prescription NSAIDs before diagnosis)Result — go to the resultAdjusted hazard ratio 1.14 95% CI 1.11–1.16Authors' conclusion
Prescription NSAID reception was more common than initiation of receiving bDMARDs among patients newly diagnosed with axSpA. Female patients appeared more likely to continue receiving NSAIDs after diagnosis, and the time to initiation of receiving bDMARDs was longer for female patients than for male patients.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) aged ≥18 years, IBM MarketScan Database 2013 to 2018 (average age at diagnosis 48.2 years; 65.7% female)
- Participants
- 174,632 patients
- Exposure
- Female vs male patients with axSpA
- Outcome
- Time from axSpA diagnosis to first prescription NSAID dispensing (no baseline NSAIDs) or bDMARD infusion/procedure claim (≥2 different prescription NSAIDs at baseline)
Methodological detailsclaims database (IBM MarketScan 2013 to 2018), survival analyses, Cox proportional hazard models
- Claims database (IBM MarketScan 2013 to 2018)
- Survival analyses
- Cox proportional hazard models
Main finding
As reported in the abstract
Time to NSAID initiation (those without ≥2 different prescription NSAIDs before diagnosis)
Adjusted hazard ratio
1.14
95% CI 1.11–1.16
By group
Femalevs Male
aHR 1.14 (95% CI 1.11–1.16)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Time to bDMARD initiation (those with ≥2 different prescription NSAIDs at baseline)Time longer for female patients | 0.61 (0.52–0.72) | |
| 0.512Adjusted hazard ratio (log scale) |
- Time to bDMARD initiation (those with ≥2 different prescription nonsteroidal anti-inflammatory drugs (NSAIDs) at baseline) — Received a bDMARD (baseline ≥2 NSAIDs)
- 4.2%
- Time to bDMARD initiation (those with ≥2 different prescription NSAIDs at baseline) — Continued NSAIDs after diagnosis (baseline ≥2 NSAIDs)
- 77.9%
Original publication
Sex Differences in Time to Initiate Nonsteroidal Anti‐Inflammatory Drugs or Biologic Disease‐Modifying Antirheumatic Drugs Among Patients With Axial Spondyloarthritis. Arthritis Care Res (Hoboken). Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →