Spondyloarthritis & psoriatic arthritis
The Burden of Spine Structural Damage on Function in Patients With Axial Spondyloarthritis: Adaptation-Mediated Uncoupling?
Authors' conclusion
Spinal damage was independently associated with physical function in axSpA, but to a lesser extent than disease activity and mobility. Moreover, incorporating CFJ assessment in the mSASSS did not improve the ability to predict function.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA)
- Participants
- 101 patients
- Outcome
- Association between spinal damage (mSASSS, CASSS) and physical function (BASFI)
Methodological detailsunivariate and multivariate analyses
- Univariate and multivariate analyses
Main finding
As reported in the abstract
- Bath Ankylosing Spondylitis Functional Index (BASFI) vs Ankylosing Spondylitis Quality of Life (ASQOL), Spearman ρ
- 0.66
- BASFI vs Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Spearman ρ
- 0.70
- BASFI vs Bath Ankylosing Spondylitis Metrology Index (BASMI), Spearman ρ
- 0.46
- BASFI vs Ankylosing Spondylitis Disease Activity Score (ASDAS), Spearman ρ
- 0.59
- BASFI vs mSASSS, Spearman ρ
- 0.29
- BASFI vs CASSS, Spearman ρ
- 0.28
- Multivariate BASFI model: BASDAI, B (P < 0.001)
- 0.76
- Multivariate BASFI model: BASMI, B (P < 0.001)
- 0.62
- Multivariate BASFI model: history of total hip arthroplasty, B (P = 0.05)
- 1.22
- Without BASMI in model: mSASSS, B (P = 0.01)
- 0.03
- Without BASMI in model: CASSS, B (P = 0.01)
- 0.02
Observational data: associations, not effects.
Original publication
The Burden of Spine Structural Damage on Function in Patients With Axial Spondyloarthritis: Adaptation-Mediated Uncoupling? J Rheumatol. Published 15 May 2024. doi:10.
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