Spondyloarthritis & psoriatic arthritis
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
Main finding · Incident CVD per increasing NSAID doseResult — go to the resultAdjusted hazard ratio 1.10 95% CI 1.08–1.13Authors' conclusion
In a real-world AS cohort, higher dose of NSAID treatment was associated with a higher risk of CVD, including ischaemic heart disease, stroke and congestive heart failure.
Study context
- Population
- Patients newly diagnosed with ankylosing spondylitis (AS) without prior cardiovascular disease (CVD), 2010–2018, Korean National Health Insurance database (mean age 36 years; 75% male)
- Participants
- 19,775 patients19,706 received non-steroidal anti-inflammatory drug (NSAIDs)
- Exposure
- Increasing NSAID dose
- Outcome
- CVD: composite of ischaemic heart disease, stroke or congestive HF
Methodological detailstime-varying exposure, Cox proportional hazard regression
- Time-varying exposure
- Cox proportional hazard regression
Main finding
Incident CVD per increasing NSAID dose
Adjusted hazard ratio
1.10
95% CI 1.08–1.13
Increasing NSAID dose
aHR 1.10 (95% CI 1.08–1.13)
Per increasing NSAID dose, as printed
As reported in the abstract
- CVD cases during 98 290 person-years
- 1663
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Incident ischaemic heart disease per increasing NSAID dose | 1.08 (1.05–1.11) | |
| Incident stroke per increasing NSAID dose | 1.09 (1.04–1.15) | |
| Incident congestive HF per increasing NSAID dose | 1.12 (1.08–1.16) | |
| 0.512Adjusted hazard ratio (log scale) |
- Incident ischaemic heart disease per increasing NSAID dose — Ischaemic heart disease cases
- 1157
- Incident stroke per increasing NSAID dose — Stroke cases
- 301
- Incident congestive HF per increasing NSAID dose — Congestive HF cases
- 613
CVD risk by NSAID dose across subgroups
- Association between NSAID dose and higher CVD risk consistent in different subgroups
Original publication
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis. Ann Rheum Dis. Published 15 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →