Spondyloarthritis & psoriatic arthritis
Risk of peripheral artery disease following ankylosing spondylitis, 2012–2023: a nationwide cohort study in South Korea
Main finding · PAD incidence per 1000 person-yearsResult — go to the resultIncidence rate ratio 1.40 95% CI 1.23–1.59Authors' conclusion
AS was associated with an increased risk of PAD, particularly among younger females
Study context
- Population
- Korean National Health Insurance Service database, 2012–2023: patients with ankylosing spondylitis (AS) and matched controlsmatched cohort
- Participants
- 2,846 vs 28,460
- Exposure
- AS vs matched controls
- ASn = 2,846
- Controlsn = 28,460reference
- Outcome
- Incident PAD (at least one outpatient visit with ICD-10 code I73.9 after the index date)
Methodological detailsnationwide, matched cohort, 3 year washout period, Cox proportional hazards models
- Nationwide
- Matched cohort
- 3 year washout period
- Cox proportional hazards models
Main finding
PAD incidence per 1000 person-years · mean follow-up 4.1 years
Incidence rate ratio
1.40
95% CI 1.23–1.59
By group
ASvs Controls
IRR 1.40 (95% CI 1.23–1.59)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Peripheral artery disease (PAD) in females aged <60 years (subgroup)
- IRR, females aged <60 years (highest excess risk)
- 1.77
PAD in males aged ≥60 years (subgroup)
- IRR, males aged ≥60 years (second-highest excess risk)
- 1.64
PAD-free survival (Kaplan-Meier)
- Lower PAD-free survival in patients with AS (log-rank p < 0.0001)
Original publication
Risk of peripheral artery disease following ankylosing spondylitis, 2012–2023: a nationwide cohort study in South Korea. Scand J Rheumatol. Published 16 September 2026. doi:10.
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