Spondyloarthritis & psoriatic arthritis
Risk of cardiovascular disease associated with long-term use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
Authors' conclusion
Prolonged NSAID treatment in AS patients may not be as harmful as in the general population regarding cardiovascular risk.
Study context
- Population
- Adults newly diagnosed with AS without prior CVD (2010–2018) and matched controls without AS, Korean National Health Insurance Databasematched cohort
- Participants
- 19,775 vs 59,325
- Exposure
- Long-term NSAID use in AS and in non-AS controls
- ASn = 19,775
- Non-AS controlsn = 59,325reference
- Outcome
- CVD: composite of ischaemic heart disease, stroke or congestive HF
Methodological detailsnationwide, matched controls (age, sex, index year)
- Nationwide
- Matched controls (age, sex, index year)
Main finding
As reported in the abstract
Incident CVD with long-term NSAID use
Adjusted hazard ratio (95% CI)
Long-term NSAID use in ASvs No long-term NSAID use in ASadjusted for age, sex, socioeconomic status, BMI, smoking, hypertension, diabetes, hyperlipidemia and TNFi use
1.06(0.94–1.20)
Long-term NSAID use in non-AS controlsvs No long-term NSAID use in non-AS controls
1.64(1.48–1.82)
Observational data: associations, not effects.
Original publication
Risk of cardiovascular disease associated with long-term use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis. Rheumatology (Oxford). Published 12 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →