Spondyloarthritis & psoriatic arthritis
Specific descriptions of axial involvement are associated with radiographic damage development after 2 years in psoriatic arthritis patients
Authors' conclusion
The likelihood of syndesmophyte formation in PsA is low. The probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
Study context
- Population
- Patients fulfilling the Classification Criteria for PsA, Belgian Epidemiological Psoriatic Arthritis Study, 17 Belgian rheumatology practices, recruited December 2012–July 20142-year spinal radiographs
- Participants
- 150 patients
- Exposure
- Presence vs absence of axial involvement
- Outcome
- New syndesmophytes (mSASSS, modified New York criteria) by axial involvement at baseline
- Follow-up
- 2 years
Methodological detailsmulticentre, logistic regression, two calibrated central readers
- Multicentre
- Logistic regression
- Two calibrated central readers
Main finding
As reported in the abstract
New syndesmophytes
- Patients with new syndesmophytes
- 11
- Probability of syndesmophytes for clinical definitions 'global assessment', 'detailed assessment', back pain (BP) and inflammatory BP (IBP); similar for presence or absence of the definition
- 0.06 and 0.08
- With elevated C reactive protein (CRP) added: probability increased two times for CBP
- two times
- With elevated CRP added: probability increased seven times for IBP
- seven times
- Radiographic sacroiliitis: probability three times higher
- three times
- Radiographic sacroiliitis combined with elevated CRP: higher chance of syndesmophytes in 2 years
- 14 times
- ORs across definitions; none statistically significant
- 0.83 to 13.80
Observational data: associations, not effects.
Original publication
Specific descriptions of axial involvement are associated with radiographic damage development after 2 years in psoriatic arthritis patients. Ann Rheum Dis. Published 11 January 2024. doi:10.
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