Spondyloarthritis & psoriatic arthritis

Dietary intake is related to disease activity and inflammation in radiographic axial spondyloarthritis: a cross-sectional multi-regional study

Scand J RheumatolPublished Cross-sectional study

Authors' conclusion

Patients with r-axSpA report lower dietary quality compared with controls. Dietary intake is related to disease activity and inflammation.

Study context

Population
Patients with radiographic axial spondyloarthritis (r-axSpA) in northern and south-western Sweden and matched SCAPIS controls155 patients matched to 604 controls
Participants
295 vs 604
Exposure
Patients with r-axSpA vs matched SCAPIS controls (dietary intake); dietary nutrients vs ASDAS and C-reactive protein (CRP) in patients
  • Patientsn = 295
  • Controlsn = 604reference
Outcome
Relationship between dietary intake (MiniMealQ food frequency questionnaire) and disease activity (ASDAS) and inflammation (CRP); dietary intake in patients vs controls
Methodological detailsmulti-regional, matched on sex, age, and geographical location, conditional logistic regression
  • Multi-regional
  • Matched on sex, age, and geographical location
  • Conditional logistic regression

Main finding

As reported in the abstract

Dietary intake, patients vs controls, and association with ASDAS and CRP
  • Patients had lower dietary fibre density and lower intake of marine omega-3 fatty acids, calcium, folate, iodine, phosphorus, potassium, selenium, vitamins A, C, and K, β-carotene, and alcohol
  • Low intake of marine omega-3 fatty acids associated with higher ASDAS
  • Lower dietary fibre density associated with elevated CRP

Observational data: associations, not effects.

Original publication

Dietary intake is related to disease activity and inflammation in radiographic axial spondyloarthritis: a cross-sectional multi-regional study. Scand J Rheumatol. Published 18 June 2025. doi:10.1080/03009742.2025.2503062

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