Spondyloarthritis & psoriatic arthritis
Cut-Offs for Disease Activity States in Axial Spondyloarthritis With Ankylosing Spondylitis Disease Activity Score (ASDAS) Based on C-Reactive Protein and ASDAS Based on Erythrocyte Sedimentation Rate: Are They Interchangeable?
Authors' conclusion
We estimated the optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-off values. However, applying the estimated cut-offs did not increase the level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states to a relevant degree.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from 9 European registries initiating a TNFi
- Participants
- 3,664 patients
- Exposure
- ASDAS-ESR vs ASDAS-CRP disease activity states
- Outcome
- Optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-offs (1.3, 2.1, and 3.5)
Methodological detailsmulticentre, 9 European registries, Youden index
- Multicentre
- 9 European registries
- Youden index
Main finding
As reported in the abstract
ASDAS-ESR cut-off corresponding to ASDAS-CRP 1.3
1.4
ASDAS-ESR cut-off corresponding to ASDAS-CRP 2.1
1.9
ASDAS-ESR cut-off corresponding to ASDAS-CRP 3.5
3.3
Observational data: associations, not effects.
Further findings
Mean
| Outcome | ASDAS-ESR | ASDAS-CRP |
|---|---|---|
| Mean ASDAS at baseline | 3.4 | 3.6 |
| Mean ASDAS at aggregated follow-up · 6, 12, or 24 months | 1.8 | 1.9 |
Proportion of discordance between ASDAS-ESR and ASDAS-CRP disease activity states, established vs estimated cut-offs
- Baseline: decreased from 22.93% to 19.81%
- Follow-up: increased from 27.17% to 28.94%
Original publication
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