Spondyloarthritis & psoriatic arthritis
Modifiable Lifestyle Factors, Genetic Susceptibility, and Incident Radiographic Axial Spondyloarthritis
Authors' conclusion
Our study suggested that adherence to a favorable lifestyle significantly reduced the risk of developing r-axSpA by attenuating the systemic inflammatory response, which was independent of genetic susceptibility to r-axSpA.
Study context
- Population
- Individuals without radiographic axial spondyloarthritis (r-axSpA) at baseline in the UK Biobank694 incident r-axSpA
- Participants
- 382,035 individuals
- Exposure
- Intermediate or favorable lifestyle vs unfavorable lifestyle
- Outcome
- Incident r-axSpA
Methodological detailsUK Biobank, Cox proportional hazards regression, polygenic risk score, mediation analysis
- UK Biobank
- Cox proportional hazards regression
- Polygenic risk score
- Mediation analysis
Main finding
As reported in the abstract
median follow-up 13.57 years
Each group vs unfavorable lifestyleHazard ratio (95% CI)
Intermediate lifestyle
0.67(0.57–0.80)
Favorable lifestyle
0.62(0.49–0.78)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Combined lifestyle and PRS: unfavorable lifestyle with high genetic riskvs favorable lifestyle with low genetic riskHighest risk | 2.18 (1.47–3.23) | |
| 0.20.5125Hazard ratio (log scale) |
Combined lifestyle and polygenic risk score (PRS): unfavorable lifestyle with high genetic risk vs favorable lifestyle with low genetic risk
- No evidence of additive and multiplicative interaction
Proportion of lifestyle–r-axSpA association mediated by systemic inflammation
- Neutrophil-to-HDL cholesterol ratio
- 0.20%
- CRP
- 10.29%
- Range across inflammatory markers
Original publication
Modifiable Lifestyle Factors, Genetic Susceptibility, and Incident Radiographic Axial Spondyloarthritis. J Rheumatol. Published 15 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →