Spondyloarthritis & psoriatic arthritis
Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization
Authors' conclusion
Observational and genetic evidence converge to suggest that BMI and glycaemic control are associated with increased psoriatic disease risk, while psoriatic disease is associated with increased CAD risk.
Study context
- Population
- UK Biobank participants; Mendelian randomization (MR) on genome-wide association data (3609 PsA and 7804 psoriasis cases)
- Participants
- 1,836 / 8,995 / 36,000
- Exposure
- PsA and psoriasis vs controls
- PsAn = 1,836
- Psoriasisn = 8,995
- Controlsn = 36,000reference
- Outcome
- BMI and risk of psoriatic disease (per 5 kg/m² increase)
Methodological detailsUK Biobank cross-sectional data, logistic models adjusted for age, sex and lifestyle factors, inverse-variance weighted method
- UK Biobank cross-sectional data
- Logistic models adjusted for age, sex and lifestyle factors
- Inverse-variance weighted method
Main finding
As reported in the abstract
BMI and PsA, cross-sectional: OR
1.31
95% CI 1.26, 1.37
Observational data: associations, not effects.
Further findings
Smoking
- In both designs, smoking more strongly associated with psoriasis than PsA
Diabetes, cross-sectional
- PsA: OR
- 1.35
- Psoriasis: OR
- 1.39
Coronary artery disease (CAD), cross-sectional
- PsA: OR
- 1.56
- Psoriasis: OR
- 1.38
Genetically predicted glycated haemoglobin (per 6.7 mmol/mol increase) and PsA risk, MR
- PsA: OR (1.02, 1.36)
- 1.18
- Not associated with psoriasis
Genetic liability to psoriatic disease and CAD risk, MR
- PsA: OR (1.003, 1.09)
- 1.05
- Psoriasis: OR (1.001, 1.06)
- 1.03
Original publication
Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomization. Rheumatology (Oxford). Published 21 July 2022. doi:10.
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