Spondyloarthritis & psoriatic arthritis
High prevalence of MASLD in psoriasis and psoriatic arthritis assessed with multiparametric magnetic resonance imaging
Authors' conclusion
Individuals with PsD exhibit higher prevalence of MASLD and MASH that was missed by blood tests and was present even in individuals with no methotrexate exposure.
Study context
- Population
- Adults with psoriasis and PsA (psoriatic disease (PsD)) receiving standard systemic therapy in secondary care (COLIPSO)COLIPSO 50
- Exposure
- PsD vs matched controls without PsD and healthy controls
- Matched controlsn = 150reference
- Healthy controlsn = 150
- Outcome
- Prevalence of MASLD/MASH (MRI)
Methodological detailsmulticentre, matched controls (age, sex, BMI and comorbidities), multiparametric MRI
- Multicentre
- Matched controls (age, sex, BMI and comorbidities)
- Multiparametric MRI
Main finding
As reported in the abstract
Steatotic liver disease prevalence
P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | PsD | Matched controls | P value |
|---|---|---|---|
| MASH prevalencePsD vs Matched controls | 22% | 3% | P < 0.001 |
- Normal liver function blood tests in PsD with liver disease
- 54% · 13 events
- Normal liver function blood tests in PsD with liver disease: 13 of 24
Liver disease by prior MTX exposure
- No significant difference with vs without prior MTX exposure
Original publication
High prevalence of MASLD in psoriasis and psoriatic arthritis assessed with multiparametric magnetic resonance imaging. Rheumatology (Oxford). Published 26 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →