Spondyloarthritis & psoriatic arthritis
More than skin-deep: visceral fat is strongly associated with disease activity, function and metabolic indices in psoriatic disease
An erratum to this article was published (Arthritis Res Ther, 4 Jul 2023 ↗)
Authors' conclusion
In this pilot study, patients with PsD revealed excessive total adipose tissue and a greater volume of metabolically unfavourable ectopic fat, including VAT, compared with BMI-matched controls, which also correlated with HAQ, disease activity and overall dysmetabolism.
Study context
- Population
- Patients with psoriatic disease (psoriasis (PsO) and psoriatic arthritis (PsA); median disease duration 15 years; median age 52 years) and BMI-matched controls
- Participants
- 30 vs 30
- Exposure
- Psoriatic disease vs BMI-matched controls
- PsDn = 30
- Controlsn = 30reference
- Outcome
- Body composition by air displacement plethysmography and MRI-derived fat segmentation (FatSegNet)
Methodological detailspilot study, BMI-matched controls
- Pilot study
- BMI-matched controls
Main finding
As reported in the abstract
MRI-derived body composition (whole-body volume, subcutaneous adipose tissue (SAT), VAT, abdominal adipose tissue (AAT), VAT/AAT, VAT/SAT)
- All MRI-derived body composition parameters higher in PsD than controls, specifically in those with active disease
Observational data: associations, not effects.
Further findings
Correlations of body composition with metabolic indices, function and disease activity
- Body mass, body fat, whole-body volume and whole-body visceral adipose tissue (VAT) correlated with higher triglycerides, cholesterol:HDL, insulin resistance, lower adiponectin, higher Health Assessment Questionnaire (HAQ) and lower minimal disease activity (MDA)
Original publication
More than skin-deep: visceral fat is strongly associated with disease activity, function and metabolic indices in psoriatic disease. Arthritis Res Ther. Published 23 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →