Spondyloarthritis & psoriatic arthritis
Myeloid-derived suppressor cells and monocytes are biomarkers of the clinical phenotype and activity of psoriatic disease
Authors' conclusion
In PsD, G-MDSCs relate to cutaneous disease activity, whereas non-classical monocytes correlate with musculoskeletal features, highlighting their role as potential biomarkers of disease activity in PsD.
Study context
- Population
- Patients with psoriatic disease (psoriasis (PsO) and PsA) and age- and sex-paired healthy controls
- Participants
- 47 vs 10
- Exposure
- Patients with psoriatic disease vs age- and sex-paired healthy controls
- Psoriatic disease (PsD)n = 47
- Healthy controlsn = 10reference
- Outcome
- Proportion of myeloid-derived suppressor cells (MDSCs) and monocyte subsets in peripheral blood in relation to clinical phenotype and disease activity (PASI, DAPSA)
Methodological detailsmultiparametric flow cytometry, multivariate logistic and linear regressions
- Multiparametric flow cytometry
- Multivariate logistic and linear regressions
Main finding
As reported in the abstract
Mature G-MDSCs
M-MDSCs
Non-classical monocytes
- G-MDSCs associated with cutaneous disease activity (Psoriasis Area and Severity Index (PASI)), β
- 5.05, P = 0.05
- Non-classical monocytes related to active PsA (Disease Activity in Psoriatic Arthritis (DAPSA)), β
- 0.68, P = 0.004
Observational data: associations, not effects.
Further findings
Patients with cutaneous features
- Increased mature G-MDSCs and decreased arginase-1 expression
Original publication
Myeloid-derived suppressor cells and monocytes are biomarkers of the clinical phenotype and activity of psoriatic disease. Rheumatology (Oxford). Published 2 September 2025. doi:10.
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