Spondyloarthritis & psoriatic arthritis
Psoriatic arthritis monocyte DNA methylomes bridge joint and skin inflammatory pathways across rheumatoid arthritis and psoriasis
Authors' conclusion
Monocyte epigenomes reveal shared inflammatory programmes across RA, PsA, and PsO, with PsA occupying a dual molecular state with joint and skin autoimmunity.
Study context
- Population
- Patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), psoriasis (PsO), undifferentiated arthritis, and matched healthy donors (peripheral blood monocytes)
- Comparison
- Peripheral blood monocyte DNA methylomes of RA, PsA, PsO and undifferentiated arthritis vs matched healthy donors
- Outcome
- Monocyte DNA methylation and transcriptional programmes
Methodological detailsgenome-wide DNA methylation profiling, single-cell RNA sequencing validation
- Genome-wide DNA methylation profiling
- Single-cell RNA sequencing validation
Main finding
As reported in the abstract
- Common methylation signature across RA, PsA and PsO, enriched in enhancers and immune regulatory pathways (IRFs, STATs, KLFs, C/EBPs)
- PsA dual epigenomic profile sharing features with RA and PsO, incl. Major histocompatibility complex (MHC) class II-related loci and FGF receptor signalling
- PsA dual disease activity correlated with methylation changes linked to inflammasome components and to cytokine signalling (IL-23/IL-17, IL-7, IL-2)
- Single-cell transcriptomics confirmed convergent alterations in antigen presentation, interferon responses, NF-κB signalling and fibroblast-associated genes, with PsA-specific transcriptional signatures
Original publication
Psoriatic arthritis monocyte DNA methylomes bridge joint and skin inflammatory pathways across rheumatoid arthritis and psoriasis. Ann Rheum Dis. Published 11 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →