Spondyloarthritis & psoriatic arthritis
Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin
Authors' conclusion
These findings show differences in diversity, bacterial composition and microbe-microbe interactions between healthy and psoriatic skin, both L and NL.
Study context
- Population
- Healthy individuals and patients with psoriasis (PsO) and psoriatic arthritis (PsA); skin swabs from upper and lower extremities
- Exposure
- Psoriatic lesional and non-lesional skin vs healthy skin
- Outcome
- Cutaneous microbiome vs healthy skin
Methodological details16S rRNA sequencing, lesional and contralateral non-lesional sampling
- 16S rRNA sequencing
- Lesional and contralateral non-lesional sampling
Main finding
As reported in the abstract
- Alpha diversity significantly reduced in psoriatic non-lesional (NL) and L skin vs healthy skin
- p<0.05
- Psoriatic samples clustered separately from healthy in beta diversity plots
- p<0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Relative abundance of Corynebacterium, NL samplesPsA vs PsO | P < 0.05 |
- Relative abundance of Corynebacterium, NL samples: higher in NL PsA vs NL PsO; potentially a biomarker for disease progression
Original publication
Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin. Ann Rheum Dis. Published 12 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →