Spondyloarthritis & psoriatic arthritis
Comparison of demographic, clinic and radiological features of patients with axial spondyloarthritis accompanying familial Mediterranean fever to patients with each condition alone
Authors' conclusion
In patients with FMF + axSpA, the age of onset of axSpA was significantly earlier, moderate to severe hip involvement and amyloidosis were more common than in patients with each condition alone.
Study context
- Population
- Patients with familial Mediterranean fever (FMF) (Tel-Hashomer criteria) and/or axial spondyloarthritis (axSpA) (modified New York criteria or active sacroiliitis on MRI), Hacettepe University Hospital
- Exposure
- FMF + axSpA vs axSpA alone and vs FMF alone
- axSpAn = 102reference
- FMFn = 136reference
- Outcome
- Age at axSpA symptom onset (FMF + axSpA vs axSpA)
Methodological detailssingle-centre, database screening (ICD-10 codes), gender-matched FMF controls
- Single-centre
- Database screening (ICD-10 codes)
- Gender-matched FMF controls
Main finding
As reported in the abstract
FMF + axSpA
21
median · IQR 17–30
axSpA
27
median · IQR 21–37
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | FMF + axSpA | axSpA | FMF | P value |
|---|---|---|---|---|
| Age at axSpA diagnosis (FMF + axSpA vs axSpA)Median, years | 23 (IQR 21–38) | 32 (IQR 24–43) | — not stated in the abstract | P = 0.001 |
| Moderate to severe hip disease (FMF + axSpA vs axSpA) | 23.4% | 4.7% | — not stated in the abstract | P < 0.001 |
| Total hip replacement (FMF + axSpA vs axSpA) | 11.2% | 2.8% | — not stated in the abstract | P = 0.016 |
| Age at FMF symptom onset (FMF + axSpA vs FMF)Median | 13 (IQR 6–30) | — not stated in the abstract | 11 (IQR 5–18) | P = 0.057 |
| Age at FMF diagnosis (FMF + axSpA vs FMF)Median, years | 23 (IQR 13–33) | — not stated in the abstract | 18 (IQR 10–31) | P = 0.033 |
| Amyloidosis (FMF + axSpA vs FMF) | 6.6% | — not stated in the abstract | 2.2% | P = 0.076 |
— not stated in the abstract
M694V variant (one or two alleles)
- More prevalent in FMF + axSpA, but the difference was not statistically significant
Original publication
Comparison of demographic, clinic and radiological features of patients with axial spondyloarthritis accompanying familial Mediterranean fever to patients with each condition alone. Scand J Rheumatol. Published 12 December 2022. doi:10.
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