Spondyloarthritis & psoriatic arthritis
The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study
Authors' conclusion
Our findings extend genetic research into the intimate link between immune cells and AS
Study context
- Population
- Large, publicly available genome-wide association studies of 731 immune cell traits and ankylosing spondylitis (AS)731 immune traits
- Comparison
- Genetically predicted immune cell traits vs AS risk, in both directions
- Outcome
- Causal association between immune cell traits and AS risk
Methodological detailsFDR correction
- FDR correction
Main finding
As reported in the abstract
Immune traits associated with AS risk (after FDR correction)
Odds ratio (95% CI)P value
CD14 - CD16 + monocyte
0.669(0.544 ≈0.823)
P = 1.46 × 10-4; PFDR = 0.043CD33dim HLA DR + CD11b +
0.589(0.446 ≈0.780)
P = 2.12 × 10-4; PFDR = 0.043Further findings
Effect of AS on immune traits (reverse direction)
| OR (95% CI) | P value | ||
|---|---|---|---|
| CD8 on HLA DR + CD8 + T cellAbstract states six immune traits; five are listed | 1.029 (1.015 ≈1.043) | P = 4.46 × 10-5; PFDR = 0.014 | |
| IgD on IgD + CD24 + B cellAbstract states six immune traits; five are listed | 0.973 (0.960 ≈0.987) | P = 1.2 × 10-4; PFDR = 0.021 | |
| IgD on IgD + CD38 - unswitched memory B cellAbstract states six immune traits; five are listed | 0.962 (0.945 ≈0.980) | P = 3.02 × 10-5; PFDR = 0.014 | |
| CD8 + natural killer T %lymphocyteAbstract states six immune traits; five are listed | 0.973 (0.959 ≈0.987) | P = 1.92 × 10-4; PFDR = 0.021 | |
| CD8 + natural killer T %T cellAbstract states six immune traits; five are listed | 0.973 (0.959 ≈0.987) | P = 1.65 × 10-4; PFDR = 0.021 | |
| 0.512Odds ratio (log scale) |
Original publication
The causal relationship between immune cells and ankylosing spondylitis: a bidirectional Mendelian randomization study. Arthritis Res Ther. Published 16 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →