Spondyloarthritis & psoriatic arthritis
Association between ankylosing spondylitis and neurodegenerative diseases: Systematic review and meta-analysis
Pooled result · Risk of NDsResult — go to the resultOdds ratio 1.36 95% CI 1.15–1.60Authors' conclusion
The current meta-analysis identified AS as a risk factor for the development of NDs.
Study context
- Population
- Studies reporting the relationship between neurodegenerative diseases (NDs) risk and ankylosing spondylitis (AS) published before April 10th, 2024 (PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials)15 comparisons
- Participants
- 851,936 participants10 studies
- Comparison
- AS vs no AS
- Outcome
- Risk of neurodegenerative diseases (NDs)
Methodological detailssubgroup analysis
- Subgroup analysis
Pooled result
Risk of NDs
Odds ratio
1.36
95% CI 1.15–1.60
P < 0.001
ASvs No AS
OR 1.36 (95% CI 1.15–1.60); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Parkinson's disease (subgroup) | 1.55 (1.31–1.83) | P < 0.001 | |
| Alzheimer's disease (subgroup)No observed association | 1.22 (0.96–1.55) | P = 0.098 | |
| Dementia (subgroup)No observed association | 1.34 (0.96–1.87) | P = 0.089 | |
| 0.512Odds ratio (log scale) |
Original publication
Association between ankylosing spondylitis and neurodegenerative diseases: Systematic review and meta-analysis. Joint Bone Spine. Published 22 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →